Long-term effects of azithromycin in patients with cystic fibrosis
نویسندگان
چکیده
منابع مشابه
Long term azithromycin therapy in patients with cystic fibrosis.
Inflammation is a central contributor to the pathogenesis of cystic fibrosis (CF) pulmonary disease; so limiting the excessive production of inflammatory mediators represents a major therapeutic strategy for slowing the decline in lung function and improving survival. The macrolide antibiotic azithromycin (AZM) has anti-inflammatory properties and immunomodulatory effects that may be beneficial...
متن کاملCYSTIC FIBROSIS Long term effects of azithromycin in patients with cystic fibrosis: a double blind, placebo controlled trial
Background: Macrolides display immunomodulatory effects that may be beneficial in chronic inflammatory pulmonary diseases. The aim of the study was to document whether long term use of azithromycin may be associated with respiratory benefits in young patients with cystic fibrosis. Methods: A multicentre, randomised, double blind, placebo controlled trial was conducted from October 2001 to June ...
متن کاملLong term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial.
BACKGROUND Macrolides display immunomodulatory effects that may be beneficial in chronic inflammatory pulmonary diseases. The aim of the study was to document whether long term use of azithromycin may be associated with respiratory benefits in young patients with cystic fibrosis. METHODS A multicentre, randomised, double blind, placebo controlled trial was conducted from October 2001 to June ...
متن کاملAzithromycin in cystic fibrosis.
We have read with interest the article by SOUTHERN and BARKER [1]. The authors critically reviewed the evidence from the randomised, controlled trials of the role of azithromycin in the management of cystic fibrosis (CF). In the three randomised, controlled studies described, the effects of up to 6 months of therapy with azithromycin in CF have been reported [2–4]. However, the controlled setti...
متن کاملEffect of long-term treatment with azithromycin on disease parameters in cystic fibrosis.
BACKGROUND Relentless chronic pulmonary inflammation is the major contributor to morbidity and mortality in patients with cystic fibrosis (CF). While immunomodulating therapies such as prednisolone and ibuprofen may be beneficial, their use is limited by side effects. Macrolides have immunomodulatory properties and long term use dramatically improves prognosis in diffuse panbronchiolitis, a con...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 2016
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2016.05.025